The clinical history of a girl aged 3 years and 6 months is presented. Purpura fulminans is a cutaneous manifestation of disseminated intravascular coagulation. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Background purpura fulminans, first described by guelliot in 1884, is a rare syndrome of intravascular thrombosis and hemorrhagic infarction of the skin that is rapidly progressive and is accompanied by vascular collapse and disseminated intravascular coagulation dic. Purpura fulminans is a hematological emergency in which there is skin necrosis and disseminated intravascular coagulation. Purpura fulminans due to staphylococcal infection, is an uncommon association which had been observed frequently in the last years. This disorder is most commonly seen in patients who develop disseminated intravascular coagulation due to various causes. This may progress rapidly to multiorgan failure caused by thrombotic occlusion of small and mediumsized blood vessels. It presents as a purpuric rash and symmetric gangrene that often necessitates amputation. The etiopathogenic mechanisms may result from abnormalities in any of the three components of hemostasis. In the presence of certain clinical features the possibility of an underlying vasculitic disease must be considered. Purpura fulminans definition of purpura fulminans by.
She was admitted in the emergency room and septic shock of gynecologic origin and. Features include tissue necrosis, small vessel thrombosis and disseminated intravascular coagulation. This syndrome usually occurs in children, but it has also been noted in a. Purpura fulminans medical definition merriamwebster. Purpura fulminans is an acute, often fatal, thrombotic disorder which manifests as blood spots, bruising and discolouration of the skin resulting from coagulation in small blood vessels within the skin and rapidly leads to skin necrosis and disseminated intravascular coagulation. There are both inherited and acquired causes of neonatal purpura fulminans. Neonatal purpura fulminans manifestation in earlyonset. Purpura results from the extravasation of blood cells into the skin andor mucous membranes giving rise to small purple coloured areas that do not disappear under pressure. Purpura fulminans pf is a haemorrhagic condition usually associated with sepsis or previous infection. Purpura, a challenging diagnose for the family physician. It can accompany infections with meningococcus, varicella, staphylococcus aureus, streptococcus and hemophilus influenzae.
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